A new series of 3-(methylthio)-1-phenyl-1H-pyrazolo[3,4-d]pyrimidine derivatives\nwas synthesized. The structures of the new derivatives were confirmed by\nthe spectral data and elemental analyses. The antitumor activity of this series\nagainst human breast adenocarcinoma cell line MCF7 was evaluated. Out of\ntwenty new derivatives, ten were revealed mild to moderate activity compared\nwith doxorubicin as a reference antitumor. Among this new series\nN-(2-chlorophenyl)-2-(3-(methylthio)-4-oxo-1-phenyl-1H-pyrazolo[3,4-d]py\nrimidin-5(4H)-yl)acetamide (13a) was found the most active one with IC50\nequal to 23 �¼M.
Loading....